ENTRY O1236 20050218 O023O123600000001 SUBENT O1236001 20050218 O023O123600100001 BIB 12 44 O123600100002 TITLE Cyclotron production of Ac-225 for targeted alpha O123600100003 therapy. O123600100004 AUTHOR (C.Apostolidis, R.Molinet, J.Mcginley, K.Abbas, O123600100005 J.Moellenbeck, A.Morgenstern) O123600100006 INSTITUTE (2ZZZITU) O123600100007 (2ZZZISP) O123600100008 (2GERKFK) O123600100009 REFERENCE (J,ARI,62,383,2005) O123600100010 HISTORY (20050111C) O123600100011 (20050218U) Last checking has been done. O123600100012 SAMPLE For the preparation of the targets containing mug- O123600100013 amounts of Ra-226, aliquots of 10-mul of stock solutionO123600100014 were slowly evaporated on thin silver foils and coveredO123600100015 with a second silver foil. The silver foil sandwiches O123600100016 were pressed and encapsulated in silver capsules, whichO123600100017 were subsequently transferred to a glove box and weldedO123600100018 gas-tight. For irradiation experiments using larger O123600100019 amounts of radium, an aliquot of radium stock solution O123600100020 typically containing 30-mg of radium-226, was mixed O123600100021 with a stock solution containing 300-mg of Ba-Cl(3) in O123600100022 dilute HCL. Barium was used as matrix due to the O123600100023 similar chemical properties of Ba- and Ra. The mixture O123600100024 was evaporated, the residual solid phase was ground in O123600100025 amortar and pressed into a pellet of 16-mm in diameter O123600100026 and 0.8-1.0-mm in height. Subsequently, the pellets O123600100027 were enclosed in silver capsules which were welded gas-O123600100028 tight. O123600100029 ADD-RES (COMP).The ALICE-code. O123600100030 Chemical processing method O123600100031 COMMENT -By authors. The radium elute was analysed for isotopicO123600100032 composition using alpha- and gamma-spectrometry and O123600100033 conditioned to be used again for target preparation. O123600100034 FACILITY (CYCLO,2GERKFK) A 28-MeV proton beam. O123600100035 METHOD (CHSEP) O123600100036 (SITA,EXTB) O123600100037 (ACTIV) Series of identical Ra-targets containing O123600100038 constant amounts of Ra-226 (12.5-mug) were irradiated O123600100039 for 7-hr with a proton current of 10-muA. O123600100040 (EDEG) Silver foils of varying thickness were used forO123600100041 energy attenuation. O123600100042 (GSPEC) And alpha spectrometry. O123600100043 ERR-ANALYS (DATA-ERR).The uncertainty is reported by authors in O123600100044 table. O123600100045 STATUS (TABLE) In the paper. O123600100046 ENDBIB 44 0 O123600100047 NOCOMMON 0 0 O123600100048 ENDSUBENT 47 0 O123600199999 SUBENT O1236002 20050218 O023O123600200001 BIB 4 6 O123600200002 REACTION (88-RA-226(P,2N)89-AC-225,,SIG) O123600200003 DECAY-DATA (89-AC-225,10.D) O123600200004 COMMENT -By authors. The formation of Ac-226 and Ac-224 was O123600200005 found to be negligible with respect to the isotopic O123600200006 purity of the actinium product. O123600200007 MISC-COL (MISC) Silver foil thickness. O123600200008 ENDBIB 6 0 O123600200009 NOCOMMON 0 0 O123600200010 DATA 4 5 O123600200011 EN DATA DATA-ERR MISC O123600200012 MEV MB MB MM O123600200013 8.8 8.5 4.2 1.26 O123600200014 12.8 250. 34. 1.08 O123600200015 16.8 710. 68. 0.86 O123600200016 20.8 200. 30. 0.58 O123600200017 24.8 38. 8.5 0.27 O123600200018 ENDDATA 7 0 O123600200019 ENDSUBENT 18 0 O123600299999 ENDENTRY 2 0 O123699999999